Efectividad cemiplimab en el cáncer de células escamosas, a propósito de un caso / Cemiplimab effectiveness in squamous cell cancer, a case report

Cemiplimab ha mostrado una actividad antitumoral sustancial en pacientes con carcinoma cutáneo de células escamosas. Los pacientes con carcinoma epidermoide cutáneo localmente avanzado tienen un pronóstico precario con la terapia sistémica convencional. Presentamos un caso clínico de la seguridad y la actividad antitumoral de cemiplimab en un paciente con carcinoma epidermoide cutáneo localmente avanzado. (AU)

Cemiplimab has shown substantial antitumor activity in patients with cutaneous squamous cell carcinoma. Patients with locally advanced cutaneous squamous cell carcinoma have a poor prognosis with conventional systemic therapy. We present a case report of the safety and antitumor activity of cemiplimab in a patient with locally advanced cutaneous squamous cell carcinoma. (AU)

A multicentre phase II study to evaluate sequential docetaxel followed by capecitabine treatment in anthracycline-pretreated HER-2-negative patients with metastatic breast cancer

INTRODUCTION: Treatment of HER-2-negative metastatic breast cancer (MBC) patients after anthracycline exposure is controversial. Docetaxel/capecitabine is a promising regimen, but the administration schedule is not well established. MATERIALS AND METHODS: Treatment included 3 cycles of docetaxel 100 mg/m2 day 1 every 21 days followed by 3 cycles of capecitabine 1250 mg/m2/12 h days 1-14. Patients not progressing were maintained with capecitabine 900 mg/m2/12 h on days 1-14 every 21 days until progression or unacceptable toxicity. RESULTS: Fifty-three anthracycline-pretreated patients were enrolled: median age 54 years, ECOG grade 0-1 86.7%. Most of the women received adjuvant chemotherapy (81%) and 5 patients (9%) had had prior metastatic chemotherapy treatment. Median time from anthracycline exposure was 29 months. ORR (intent-to-treatment analysis) after the sequential therapy was 51% (CI 95% 37-65) with 15% (CI 95% 7-28) of patients reaching complete responses. Median time to progression was 8.2 (CI 95% 7.1-10.7) months, with 61.9% (CI 95% 45.6-76.4) of the patients free of disease after 6 months. Median overall survival was not reached after a median follow-up of 10.4 months, and 75% of the patients were alive after 14.3 months. Survival rate after 12 months was 81.1% (CI 95% 68.0-90.6). The most frequent NCI grade 3-4 toxicities were hair loss (28.3%), asthenia (15.1%), stomatitis (11.32%) and nausea (11.32%). Severe hand-foot syndrome rate was 7.5%. CONCLUSIONS: Sequential docetaxel-capecitabine is feasible, effective and well tolerated in first-line MBC treatment. Evaluation of this schedule in randomised studies is warranted (AU)

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[Papilar thyroid carcinoma. An unusual clinic]. / Carcinoma papilar de tiroides de localizacion inusual.

The Papillary carcinoma is the most frequent neoplasic tumour of the thyroid gland. It accounts for 70-75% of all malignant thyroid tumours. In 80-90% of cases it presents as a slow-growing single thyroid node. Nevertheless, in 10-26% of cases, the initial presentation is a lateral neck mass without palpable thyroid mass. We present the case of a 67 year- old patient who attended to the ENT out-patient clinic with a lateral neck mass which had been growing slowly over the course of number of years.

[Unifocal eosinophilic granuloma of the temporal bone]. / Granuloma eosinófilo unifocal de hueso temporal.

We present a case of a twelve year old child with a eosinophilic granuloma of the temporal bone. The eosinophilic granuloma is the most frecuent and most benign form of the histiocytosis of the Langerhans cells. The frecuency of the othological manifestations of this condition varies between 15-60 percent and radiologically, the images are characterized by litho-lesions with sharp edges. The diagnosis is histological and the treatment includes surgical intervention accompanied by inter-lesion corticoid-therapy and/or radiotherapy.

Carcinoma papilar de tiroides de localización inusual / Papilar thyroid carcinoma. An unusual clinic

El carcinoma papilar es el tumor más frecuente de la glándula tiroides, con una frecuencia del 70-75% de todos los cánceres tiroideos. En el 80-90% de los casos se manifesta como un nódulo tiroideo único de crecimiento lento. Sin embargo, en el 10-26%; la forma de presentación es de una tumoración laterocervical aislada en ausencia de una masa tiroidea palpable. Presentamos el caso de un paciente de 67 años de edad que acudió a consulta por tumoración laterocervical de varios años de evolución

The Papillary carcinoma is the most frequent neoplasic tumour of the thyroid gland. It accounts for 70-75% of all malignant thyroid tumours. In 80-90% of cases it presents as a slow-growing single thyroid node. Nevertheless, in 10-26% of cases, the initial presentation is a lateral neck mass without palpable thyroid mass. We present the case of a 67 year- old patient who attended to the ENT out-patient clinic with a lateral neck mass which had been growing slowly over the course of number of years

Granuloma eosinófilo unifocal de hueso temporal / Unifocal eosinophilic granuloma of the temporal bone

Presentamos el caso de un niño de 12 años de edad con un granuloma eosinófilo del hueso temporal. El granuloma eosinófilo es la forma más benigna y frecuente de la histiocitosis de células Langerhans. La frecuencia de manifestaciones otológicas varía entre un 15-60% y radiológicamente las imágenes se caracterizan por lesiones líticas de bordes cortantes. El diagnóstico es necesariamente histológico y el tratamiento incluye resección quirúrgica acompañado de corticoterapia intralesional y/o radioterapia

We present a case of a twelve year old child with a eosinophilic granuloma of the temporal bone. The eosinophilic granuloma is the most frecuent and most benign form of the histiocytosis of the Langerhans cells. The frecuency of the othological manifestations of this condition varies between 15-60 percent and radiologically, the images are characterized by litho-lesions with sharp edges. The diagnosis is histological and the treatment includes surgical intervention accompanied by inter-lesion corticoid-therapy and/or radiotherapy

[Child nasopharyngeal angiofibroma]. / Angiofibroma nasofaringeo infantil.

Angiofibromas are benign tumors, highly vascularized, that affect male adolescents and young men. We present a clinical case of an 11-year-old patient with an angiofibroma of the nasopharynx, reviewing the etiopathogenic theories and current surgical approaches.

Angiofibroma nasofaríngeo infantil / Child nasopharyngeal angiofibroma

Los angiofibromas son tumores benignos con elevada vascularización que afectan a varones jóvenes y adolescentes. Los casos descritos en niños son excepcionales. Exponemos el caso clínico de un paciente de 11 años de edad con un angiofibroma nasofaringeo revisando las teorias etiopatogénicas y posibles abordajes quirúrgicos

Angiofibromas are benign tumors, highly vascularized, that affect male adolescents and young men. We present a c1inical case of an 11 year old patient with an angiofibroma ofthe nasopharynx, reviewing the etiopathogenic theories and current surgical approaches

Enfermedad de Hodgkin epitroclear. Aportación de un nuevo caso / Hodgkin´s disease presenting in epitrochlear nodes. A new case

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